期刊
JOURNAL OF CROHNS & COLITIS
卷 4, 期 5, 页码 603-605出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.crohns.2010.05.001
关键词
Infliximab; Crohn s; BCG; Pregnancy; Vaccination
We present the case of a 28 year old lady with refractory Crohn s Disease treated with infliximab throughout her pregnancy Her baby was born healthy and received a Bacillus Calmette Guerin (BCG) vaccine aged 3 months Soon after this the infant became unwell and died aged 4 5 months At post mortem the cause of death was attributed to an unusual complication of the BCG vaccine, known as disseminated BCG BCG vaccination is contraindicated in individuals who are receiving immunosuppressive drugs We recommend physicians should exercise caution before such vaccines are used in infants born to mothers taking anti TNF therapies or other potentially immunosuppressive IgG1 antibodies (C) 2010 European Crohns and Colitis Organisation Published by Elsevier B V All rights reserved
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