期刊
JOURNAL OF CRITICAL CARE
卷 47, 期 -, 页码 324-330出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.jcrc.2018.04.003
关键词
Muscle weakness; ICU acquired weakness; Ultrasonography; Quadriceps muscle
资金
- National Institutes of Health [NHLBI T32HL007891, NHLBI K23 HL102254, NHLBI R56122474, NHLBI K24 HL115354]
Purpose: The objective of this study is to describe the relationship between two quantitative muscle ultrasound measures, the rectus lemons cross-sectional area (RF-CSA) and quadriceps muscle thickness, with volitional measures of strength and function in critically ill patients with sepsis. Materials and methods: We performed a prospective study of patients admitted to a medical ICU with sepsis and shock or respiratory failure. We examined the association of two ultrasound measurements - the RF-CSA and quadriceps muscle thickness - with strength and function at day 7. Strength was determined using the Medical Research Council Score and function using Physical Function in the ICU Test, scored. Results: Twenty-nine patients were enrolled; 19 patients had outcome testing performed. Over 7 days, RF-CSA and thickness decreased by an average of 23.2% and 17.9%, respectively. The rate of change per day of RF-CSA displayed a moderate correlation with strength (rho 0.51, p-value 0.03) on day 7. Baseline and day 7 RF-CSA did not show a significant correlation with either outcome. Quadriceps muscle thickness did not significantly correlate with either outcome. Conclusions: Muscle atrophy as detected by the rate of change in RF-CSA moderately correlated with strength one week after sepsis admission. (C) 2018 Elsevier Inc. All rights reserved.
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