期刊
JOURNAL OF CRANIOFACIAL SURGERY
卷 24, 期 6, 页码 1927-1930出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SCS.0b013e3182a3050c
关键词
Silk fibroin; 4-hexylresorcinol; membrane; bone regeneration
类别
资金
- Rural Development Administration, Republic of Korea [PJ009013]
The objective of this study was to demonstrate that a silk fibroin (SF) and 4-hexylresorcinol (4-HR) incorporation membrane could be used for a guided bone regeneration technique. Fourier transform infrared measurements were obtained to determine change of physical property of SF membrane by 4-HR incorporation. Two peri-implant defects, 3.0 x 5.0 mm (width x length), were prepared on the lateral side of the implant hole in the tibia of New Zealand white rabbits (n = 8). The peri-implant defect was left unfilled in the control group. Silk fibroin + 4-HR membrane was applied to the peri-implant defect in the experimental group. The 8 animals were killed at 8 weeks after implantation. Subsequently, removal torque test and histomorphometric evaluation were done. Fourier transform infrared spectroscopy showed no specific chemical interaction between 4-HR and SF. In the histomorphometric analysis, the mean bone regeneration was 18.3 +/- 1.9 mm(2) in the experimental group and 9.3 +/- 0.9 mm(2) in the control group ( P = 0.004). In conclusion, the SF and 4-HR incorporation membrane successfully regenerated bone in the rabbit tibia peri-implant bone defect model.
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