Cellular blue nevus (CBN) lymph node metastases of the neck with no primary skin lesion: A case report and review of literature

A case of cervical lymph node infiltration by a benign cellular blue nevus (CBN) and a 27-year disease history is presented Dermal dendritic melanocytes and pigmented spindle cells presented no histological evidence of malignancy (CD34-, desmin-, PanCy-, HMB-45+, anti-S-100+, Bcl-2+, MART-1+, focally expression of melan A, 1% Ki-67+ of the tumour cell nucleoli) The differentiation of the benign blue nevus (BN) from a malignant blue nevus (MBN) and a malignant melanoma (MM) is still a challenge Because of the malignant transformation potential of 5 2-6 3% a histological examination and a conservative surgical approach with close follow up are mandatory (C) 2010 European Association for Cranio-Maxillo-Facial Surgery