Synthesis, characterization, and biological activity of five new mixed-ligand palladium(II) complexes with ethylenediamine and 4-toluenesulfonyl-L-amino acid dianion

Five new palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and en, [Pd(en)(TsserNO)] (1), [Pd(en)(TsglyNO)] (2), [Pd(en)(TsalaNO)]center dot 1.5H(2)O (3), [Pd(en) (TsleuNO)]center dot H2O (4), and [Pd(en)(TspheNO)]center dot 2H(2)O (5), have been synthesized and characterized by elemental analysis, IR, UV, 1 H NMR, and mass spectrometry. Crystal structure of 1 has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate 1-5 exert cytotoxic effects against HL-60, Bel-7402, BGC-823, and KB cell lines and 5 displays the best cytotoxicity. The structure-activity relationships suggest that both amino acid and N-containing ligands have important effects on cytotoxicity.