Cell experimental studies on sonoporation: State of the art and remaining problems

Sonoporation is the formation of transient pores on cell membrane by ultrasound exposure. Sonoporation can be applied to the increasing delivery of drug or gene into cells. However, there are some problems encountered in sonoporation studies. The mechanisms to produce sonoporation are very complicated; there are too many experimental parameters affecting the sonoporation results; and there are many bio-effects accompanied with sonoporation. In the article, the cell experimental studies on sonoporation were sorted, including experimental methods, mechanisms to produce sonoporation, correlations between sonoporation experimental parameters and results, and bioeffects accompanied with sonoporation. We'd like to make the concepts about sonoporation clearer. The sonoporation technology may be a promising auxiliary technology to promote drug or gene therapy in the future. (C) 2013 Elsevier B.V. All rights reserved.