期刊
JOURNAL OF CONTROLLED RELEASE
卷 192, 期 -, 页码 174-181出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.07.007
关键词
Microneedles; Neointimal hyperplasia; Drug delivery; Restenosis; Grafting surgery
资金
- Korea Healthcare Technology R&D Project, Ministry for Health & Welfare Affairs, Republic of Korea [HI08C2149]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2013R1A2A2A01069228]
Restenosis often occurs at the site of vascular grafting and may become fatal for patients. Restenosis at anastomosis sites is due to neointimal hyperplasia (NH) and difficult to treat with conventional treatments. Such abnormal growth of smooth muscle cells in tunica media of vascular tissue can be reduced by delivering anti-proliferation drugs such as paclitaxel (PTX) to the inner vascular layer. Drug eluting stents (DES) or drug eluting balloon (DEB) have been developed to treat such vascular diseases. However, they are less efficient in drug delivery due to the drug loss to blood stream and inadequate to be applied to re-stenotic area in the presence of stent or anastomosis sites. Recently, we have introduced microneedle cuff (MNC) as perivascular delivery devices to achieve high delivery efficiency to tunica media. In this study, we investigated in vivo microneedle insertion and efficacy in treating NH using a rabbit balloon injury model. Microneedle shape was optimized for reliable insertion into tunica media layer. Uniform distribution of PTX in tunica media delivered by MNC devices was also confirmed. Animal study demonstrated significant NH reduction by MNC treatments and much higher delivery efficiency than flat type devices. (C) 2014 Elsevier B.V. All rights reserved.
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