期刊
JOURNAL OF CONTROLLED RELEASE
卷 190, 期 -, 页码 228-239出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.05.024
关键词
Cell sheet; Regenerative medicine
资金
- Japan Society for the Promotion of Science
- Council for Science and Technology Policy
- Japan Research Promotion Society for Cardiovascular Diseases and Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program
- Project for Developing Innovation Systems, Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan
After the biotech medicine era, regenerative medicine is expected to be an advanced medicine that is capable of curing patients with difficult-to-treat diseases and physically impaired function. Our original scaffold-free cell sheet-based tissue engineering technology enables transplanted cells to be engrafted for a long time, while fully maintaining their viability. This technology has already been applied to various diseases in the clinical setting, including the cornea, esophagus, heart, periodontal ligament, and cartilage using autologous cells. Transplanted cell sheets not only replace the injured tissue and compensate for impaired function, but also deliver growth factors and cytokines in a spatiotemporal manner over a prolonged period, which leads to promotion of tissue repair. Moreover, the integration of stemcell biology and cell sheet technology with sufficient vascularization opens possibilities for fabrication of human three-dimensional vascularized dense and intact tissue grafts for regenerative medicine to parenchymal organs. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据