期刊
JOURNAL OF CONTROLLED RELEASE
卷 190, 期 -, 页码 531-541出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.03.050
关键词
Cellular hitchhiking; Cell-mediated drug delivery; Nanomedicine; Nanotechnology; Nanoparticles; Blood
资金
- National Science Foundation [DGE-1144085]
- National Institutes of Health [R01DK097379]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK097379] Funding Source: NIH RePORTER
Cellular hitchhiking leverages the use of circulatory cells to enhance the biological outcome of nanoparticle drug delivery systems, which often suffer from poor circulation time and limited targeting. Cellular hitchhiking utilizes the natural abilities of circulatory cells to: (i) navigate the vasculature while avoiding immune system clearance, (ii) remain relatively inert until needed and (iii) perform specific functions, including nutrient delivery to tissues, clearance of pathogens, and immune system surveillance. A variety of synthetic nanoparticles attempt to mimic these functional attributes of circulatory cells for drug delivery purposes. By combining the advantages of circulatory cells and synthetic nanoparticles, many advanced drug delivery systems have been developed that adopt the concept of cellular hitchhiking. Here, we review the development and specific applications of cellular hitchhiking-based drug delivery systems. (C) 2014 Elsevier B.V. All rights reserved.
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