期刊
JOURNAL OF CONTROLLED RELEASE
卷 169, 期 1-2, 页码 112-125出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2013.03.036
关键词
Drug delivery; Thermosensitive liposomes; Thermosensitive polymers; Chemotherapy
资金
- NIBIB NIH HHS [R21 EB009493] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008541] Funding Source: Medline
Liposomes are a promising class of nanomedicine with the potential to provide site-specific chemotherapy, thus improving the quality of cancer patient care. First-generation liposomes have emerged as one of the first nanomedicines used clinically for localized delivery of chemotherapy. Second-generation liposomes, i.e. stimuli-responsive liposomes, have the potential to not only provide site-specific chemotherapy, but also triggered drug release and thus greater spatial and temporal control of therapy. Temperature-sensitive liposomes are an especially attractive option, as tumors can be heated in a controlled and predictable manner with external energy sources. Traditional thermosensitive liposomes are composed of lipids that undergo a gel-to-liquid phase transition at several degrees above physiological temperature. More recently, temperature-sensitization of liposomes has been demonstrated with the use of lysolipids and synthetic temperature-sensitive polymers. The design, drug release behavior, and clinical potential of various temperature-sensitive liposomes, as well as the various heating modalities used to trigger release, are discussed in this review. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据