期刊
JOURNAL OF CONTROLLED RELEASE
卷 172, 期 3, 页码 1020-1034出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2013.10.012
关键词
Multifunctional; Nanoparticles; Immune activation; Anticancer drug delivery; Theranostics
资金
- NSF [CBET 0932517]
- NSF ARI-R2 [CMMI-0963224]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0932517] Funding Source: National Science Foundation
Nanoparticles (NPs) have been extensively investigated for applications in both experimental and clinical settings to improve delivery efficiency of therapeutic and diagnostic agents. Most recently, novel multifunctional nanoparticles have attracted much attention because of their ability to carry diverse functionalities to achieve effective synergistic therapeutic treatments. Multifunctional NPs have been designed to co-deliver multiple components, target the delivery of drugs by surface functionalization, and realize therapy and diagnosis simultaneously. In this review, various materials of diverse chemistries for fabricating multifunctional NPs with distinctive architectures are discussed and compared. Recent progress involving multifunctional NPs for immune activation, anticancer drug delivery, and synergistic theranostics is the focus of this review. Overall, this comprehensive review demonstrates that multifunctional NPs have distinctive properties that make them highly suitable for targeted therapeutic delivery in these areas. (C) 2013 Elsevier B.V. All rights reserved.
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