期刊
JOURNAL OF CONTROLLED RELEASE
卷 166, 期 2, 页码 130-138出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2012.12.007
关键词
HPMA copolymers; Gold nanorods; Photothermal therapy; Hyperthermia; MRI; Drug delivery
资金
- Department of Defense Prostate Cancer Predoctoral Training Award [PC094496]
- National Institutes of Health [EB-R01EB7171]
- Utah Science, Technology, and Research (USTAR) Initiative
Effective drug delivery to tumors requires both transport through the vasculature and tumor interstitium. Previously, it was shown that gold nanorod (GNR) mediated plasmonic photothermal therapy (PPTT) is capable of increasing the overall accumulation of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers in prostate tumors. In the present study, it is demonstrated that PPTT is also capable of increasing the distribution of these conjugates in tumors. Gadolinium labeled HPMA copolymers were administered to mice bearing prostate tumors immediately before treatment of the right tumor with PPTT. The left tumor served as internal, untreated control. Magnetic resonance imaging (MRI) of both tumors showed that PPTT was capable of improving the tumor mass penetration of HPMA copolymers. Thermal enhancement of delivery, roughly 1.5-fold, to both the tumor center and periphery was observed. Confocal microscopy of fluorescently labeled copolymers corroborates these findings in that PPTT is capable of delivering more HPMA copolymers to the tumor's center and periphery. These results further demonstrate that PPTT is a useful tool to improve the delivery of polymer-drug conjugates. (C) 2012 Elsevier B.V. All rights reserved.
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