期刊
JOURNAL OF CONTROLLED RELEASE
卷 161, 期 2, 页码 377-388出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2012.04.008
关键词
Adenovirus; Adeno-associated virus; Gene therapy; Retrovirus; Viral vectors
资金
- Telethon Foundation, Italy [GGP11068]
- European Research Council (ERC) [20090506]
- Project CTC from the Fondazione CRTrieste, Trieste, Italy
After over 20 years from the first application of gene transfer in humans, gene therapy is now a mature discipline, which has progressively overcome several of the hurdles that prevented clinical success in the early stages of application. So far, the vast majority of gene therapy clinical trials have exploited viral vectors as very efficient nucleic acid delivery vehicles both in vivo and ex vivo. Here we summarize the current status of viral gene transfer for clinical applications, with special emphasis on the molecular properties of the major classes of viral vectors and the information so far obtained from gene therapy clinical trials. (C) 2012 Elsevier B.V. All rights reserved.
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