期刊
JOURNAL OF CONTROLLED RELEASE
卷 164, 期 2, 页码 236-246出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2012.10.007
关键词
Nanomedicine; Drug delivery; Size analysis; Ligand density; Active targeting; Passive uptake
资金
- National Cancer Institute [RC1 CA-147096]
- Lilly Endowment (College of Pharmacy)
- Purdue University Center for Cancer Research
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
Nanomedicine-based approaches to cancer treatment face several challenges that differ from those encountered by conventional medicines during clinical development. A systematic exploration of these issues has led us to identify the following needs and opportunities for further development: (1) robust and general methods for the accurate characterization of nanoparticle size, shape, and composition; (2) scalable approaches for producing nanomedicines with optimized bioavailability and excretion profiles; (3) particle engineering for maintaining low levels of nonspecific cytotoxicity and sufficient stability during storage; (4) optimization of surface chemistries for maximum targeted delivery and minimum nonspecific adsorption; (5) practical methods for quantifying ligand density and distributions on multivalent nanocarriers; and (6) the design of multifunctional nanomedicines for novel combination therapies with supportable levels of bioaccumulation. (C) 2012 Elsevier B.V. All rights reserved.
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