期刊
JOURNAL OF CONTROLLED RELEASE
卷 147, 期 3, 页码 428-435出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2010.07.123
关键词
Block copolymer; Vesicle; Polymersome; Doxorubicin; Drug delivery; Controlled release
资金
- CNRS
- Region Aquitaine
- ANR
- EU
Doxorubicin (Dox), an anthracycline anticancer drug, was successfully incorporated into block copolymer vesicles of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) by a solvent-displacement (nanoprecipitation) method. pH conditions were shown to have a strong influence on loading capacity and release profiles. Substantial drug loading (47% w/w) was achieved at pH 10.5. After pH neutralization, aqueous dispersions of drug-loaded vesicles were found stable for a prolonged period of time (at least 6 months) without vesicle disruption or drug precipitation. Dox-loaded vesicles exhibited in vitro pH and temperature-dependent drug release profiles: release kinetics fastened in acid conditions or by increasing temperature. These features strongly support the interest of developing PTMC-b-PGA polymersomes as carriers for the controlled delivery of Dox. (C) 2010 Elsevier B.V. All rights reserved.
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