期刊
JOURNAL OF CONTROLLED RELEASE
卷 133, 期 2, 页码 109-118出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2008.09.085
关键词
Ultrasound contrast agent; Polymer-shelled microcapsule; Acoustic properties; Drug delivery; Lipophilic drug
资金
- Dutch ministry of economic affairs [nr IS042035]
The use of ultrasound contrast agents as local drug delivery systems Continues to grow. Current limitations are the amount of drug that can be incorporated as well as the efficiency of drug release Upon insonification. This Study focuses oil the synthesis and characterisation of novel polymeric microcapsules for ultrasound-triggered delivery of lipophilic drugs. Microcapsules with a shell Of fluorinated end-capped poly(L-lactic acid) were made through pre-mix membrane emulsification and contained, apart from a gaseous phase, different amounts of hexadecane oil as a drug-carrier reservoir. Mean number weighted diameters were between 1.22 mu m and 1.31 mu m. High-speed imaging at similar to 10 million fames per second showed that for low acoustic pressures (1 MHz, 0.24 MPa) microcapsules compressed but remained intact. At higher diagnostic pressures of 0.51 MPa, microcapsules cracked, thereby releasing the encapsulated gas and model lipophilic drug, U-Sing conventional ultrasound B-mode imaging at a frequency of 2.5 MHz, a marked enhancement of scatter intensity over a tissue-mimicking phantom was observed for all differently loaded microcapsules. The partially oil-filled microcapsules with high drug loads and well-defined acoustic activation thresholds have great potential for ultrasound-triggered local delivery of lipophilic drugs under ultrasound image-guidance. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据