期刊
JOURNAL OF CONTROLLED RELEASE
卷 134, 期 3, 页码 201-206出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2008.11.017
关键词
Osmotic tablet; Oral controlled-release; Extrudable core technology; Monolithic osmotic tablet; High dose drug delivery
A new controlled-release, extrudable core system (ECS) tablet has been developed which osmotically delivers high doses of low solubility active pharmaceutical ingredients (API's). The tablet has a single core formed in a modified oval shape with a semi-permeable coating. The core contains hydroxyethylcellulose, which serves to entrain the API particles as they are extruded out a hole in the coating at one end of the tablet, and a sugar, which provides the osmotic driving force for water imbibing. The dosage form has been successfully shown to control delivery of API over a range of delivery rates even with 50% of the tablet being API (up to about 500 mg). (C) 2008 Elsevier B.V. All rights reserved.
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