期刊
JOURNAL OF CONTROLLED RELEASE
卷 140, 期 2, 页码 141-147出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2009.08.003
关键词
Hyperbranched polyglycerol; Amphiphilic copolymer; Biocompatibility; Protein; Biomacromolecule delivery
资金
- National Natural Science Foundation of China [20804021]
- Natural Science Foundation of Tianjin [08JCYBJC00300]
- Ph.D. Programs Foundation for New Teachers of Ministry of Education of China [200800551030]
Amphiphilic copolymers with polylactic acid (PLA) chains grafted onto hyperbranched polyglycerol (HPG) have been synthesized and characterized. The copolymer nanoparticles with corona and core structure were formed by self-assembly in aqueous solution. The loading capacity and association efficiency were up to 23% and 86%, respectively. Protein release profiles with different copolymer compositions and BSA concentrations all showed a burst effect followed by a continuous release phase. The released BSA from the copolymer nanoparticles remained in its original structure over a period of 4 days, as testified by circular dichroism spectroscopy. Furthermore, cell viability research suggested good biocompatibility of the copolymer nanoparticles, which have a promising potential for protein delivery system. (C) 2009 Elsevier B.V. All rights reserved.
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