期刊
JOURNAL OF CONTROLLED RELEASE
卷 132, 期 3, 页码 230-235出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2008.06.012
关键词
Non-viral gene delivery; Neurons; Peptides; Polyethylenimine
资金
- NIH/NINDS [R21NS052030]
- NSF CAREER Award [CBET 0448547]
- University of Washington's Engineered Biomaterials Training Program [T32GM065098]
Neuron-targeted nucleic acid delivery systems are important technologies for realizing the potential of gene therapy for nervous system disorders. However, neurons are difficult cells to transfect using non-viral vectors due in part to the specific and unique delivery challenges present in these cells. We have investigated several bioactive peptides for their ability to assist in overcoming delivery barriers in mammalian cells. We summarize here our recent progress in developing and applying peptide-modified polycations for nucleic acid delivery. In addition, we present data demonstrating the potential of using multicomponent, peptide-modified polycations for nucleic acid delivery to neurons. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据