期刊
JOURNAL OF CONTAMINANT HYDROLOGY
卷 142, 期 -, 页码 50-62出版社
ELSEVIER
DOI: 10.1016/j.jconhyd.2012.09.006
关键词
Colloid deposition; Granule-associated BSA; Side-on conformation; End-on conformation; Mathematical modeling
资金
- Natural Science Foundation of China [41101475]
- Special Research Scholarship of Queen's University Belfast
Our recent study reported that conformation change of granule-associated Bovine Serum Albumin (BSA) may influence the role of the protein controlling colloid deposition in porous media (Flynn et al., 2012). The present study conceptualized the observed phenomena with an ellipsoid morphology model, describing BSA as an ellipsoid taking a side-on or end-on conformation on granular surface, and identified the following processes: (1) at low adsorbed concentrations, BSA exhibited a side-on conformation blocking colloid deposition; (2) at high adsorbed concentrations, BSA adapted to an end-on conformation promoted colloid deposition; and (3) colloid deposition on the BSA layer may progressively generate end-on molecules (sites) by conformation change of side-on BSA, resulting in sustained increasing deposition rates. Generally, the protein layer lowered colloid attenuation by the porous medium, suggesting the overall effect of BSA was inhibitory at the experimental time scale. A mathematical model was developed to interpret the ripening curves. Modeling analysis identified the site generation efficiency of colloid as a control on the ripening rate (declining rate in colloid concentrations), and this efficiency was higher for BSA adsorbed from a more dilute BSA solution. (C) 2012 Elsevier B.V. All rights reserved.
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