期刊
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
卷 35, 期 6, 页码 679-684出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RCT.0b013e3182345b0e
关键词
brain neoplasm; diagnosis; FDG; FLT; positron emission tomography; recurrence
资金
- Ministry of Health, Welfare and Family Affairs, Republic of Korea [A060775]
- Korea Health Promotion Institute [A060775] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Objective: We evaluated the diagnostic usefulness of 3'-deoxy-3'[F-18]fluorothymidine (FLT) compared with 2-[F-18]fluoro-2-deoxy-Dglucose (FDG) positron emission tomography (PET) in recurrent brain tumors. Methods: Twenty patients with suspected recurrence after surgical removal of primary tumors were studied. The uptake was assessed visually and quantified by standardized uptake value (SUV) and SUV ratio of tumor to white matter, tumor to gray matter, and tumor to normal tissue. Final diagnoses were made by histopathology or clinical and radiological follow-up. Results: Of 20 lesions, 15 were recurrences. 3'-Deoxy-3'[F-18] fluorothymidine PET showed high diagnostic sensitivity (15/ 15 [100%]) and moderate specificity (3/5 [60.0%]). 2-[F-18]fluoro-2-deoxy-D-glucose PET showed moderate diagnostic sensitivity (11/15 [73.3%]) and specificity (4/5 [80%]). All of 4 recurrent tumors without FDG uptake showed FLT uptake. Tumor-to-normal tissue ratios (3.99 +/- 1.72) of recurrent tumors on FLT PET were significantly higher than tumor-to-white matter ratios (1.96 +/- 0.93) and tumor-to-gray matter ratios (1.32 +/- 0.33) on FDGPET (P < 0.001), although SUVs (0.62 +/- 0.32) of recurrent tumors on FLT PET were lower than those (2.44 +/- 1.02) on FDG PET (P < 0.001). Conclusion: 3'-Deoxy-3'-[F-18]fluorothymidine PET has a high sensitivity but a lower specificity, which has a limited role in the diagnosis of recurrent brain tumors as a complimentary tool of magnetic resonance imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据