期刊
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
卷 33, 期 1, 页码 1-19出版社
SPRINGER
DOI: 10.1007/s10827-011-0371-7
关键词
Particle filter; Synaptic filtering; Generalized linear model
资金
- NSF
- McKnight Scholar award
- Alfred P. Sloan Research Fellowship
We discuss methods for optimally inferring the synaptic inputs to an electrotonically compact neuron, given intracellular voltage-clamp or current-clamp recordings from the postsynaptic cell. These methods are based on sequential Monte Carlo techniques (particle filtering). We demonstrate, on model data, that these methods can recover the time course of excitatory and inhibitory synaptic inputs accurately on a single trial. Depending on the observation noise level, no averaging over multiple trials may be required. However, excitatory inputs are consistently inferred more accurately than inhibitory inputs at physiological resting potentials, due to the stronger driving force associated with excitatory conductances. Once these synaptic input time courses are recovered, it becomes possible to fit (via tractable convex optimization techniques) models describing the relationship between the sensory stimulus and the observed synaptic input. We develop both parametric and nonparametric expectation-maximization (EM) algorithms that consist of alternating iterations between these synaptic recovery and model estimation steps. We employ a fast, robust convex optimization-based method to effectively initialize the filter; these fast methods may be of independent interest. The proposed methods could be applied to better understand the balance between excitation and inhibition in sensory processing in vivo.
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