期刊
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
卷 26, 期 2, 页码 289-301出版社
SPRINGER
DOI: 10.1007/s10827-008-0111-9
关键词
Phase response curves; Cortex; Neuromodulation; Muscarine; Acetylcholine; Pyramidal neuron; Conductance-based model; Multi-compartmental model; M-current
资金
- Deutsche Forschungsgemeinschaft
- Gatsby Foundation
- CNRS
- Marie Curie EXT BIND
- Howard Hughes Medical Institute
The response of an oscillator to perturbations is described by its phase-response curve (PRC), which is related to the type of bifurcation leading from rest to tonic spiking. In a recent experimental study, we have shown that the type of PRC in cortical pyramidal neurons can be switched by cholinergic neuromodulation from type II (biphasic) to type I (monophasic). We explored how intrinsic mechanisms affected by acetylcholine influence the PRC using three different types of neuronal models: a theta neuron, single-compartment neurons and a multi-compartment neuron. In all of these models a decrease in the amount of a spike-frequency adaptation current was a necessary and sufficient condition for the shape of the PRC to change from biphasic (type II) to purely positive (type I).
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