期刊
JOURNAL OF COMPUTATIONAL CHEMISTRY
卷 29, 期 8, 页码 1292-1305出版社
WILEY
DOI: 10.1002/jcc.20891
关键词
RNA secondary structures; stochastic model; weighted improved relative entropy; similarity search; phygenetic relationship
With more and more RNA secondary structures accumulated, the need for comparing different RNA secondary structures often arises in function prediction and evolutionary analysis. Numerous efficient algorithms were developed for comparing different RNA secondary structures, but challenges remain. In this article, a new statistical measure extending the notion of relative entropy based on the proposed stochastic model is evaluated for RNA secondary structures. The results obtained from several experiments on real datasets have shown the effectiveness of the proposed approach. Moreover, the time complexity of our method is favorable by comparing with that of the existing methods which solve the similar problem. (C) 2008 Wiley Periodicals, Inc.
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