期刊
JOURNAL OF COMPUTATIONAL BIOLOGY
卷 19, 期 6, 页码 662-678出版社
MARY ANN LIEBERT INC
DOI: 10.1089/cmb.2012.0020
关键词
cancer genomics; algorithms; combinatorial pattern matching; gene amplification
类别
资金
- NIH [5RO1-HG004962]
- NSF [CCF-1115206]
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [1115206] Funding Source: National Science Foundation
The breakage-fusion-bridge (BFB) mechanism was proposed over seven decades ago and is a source of genomic variability and gene amplification in cancer. Here we formally model and analyze the BFB mechanism, to our knowledge the first time this has been undertaken. We show that BFB can be modeled as successive inverted prefix duplications of a string. Using this model, we show that BFB can achieve a surprisingly broad range of amplification patterns. We find that a sequence of BFB operations can be found that nearly fits most patterns of copy number increases along a chromosome. We conclude that this limits the usefulness of methods like array CGH for detecting BFB.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据