期刊
NMR IN BIOMEDICINE
卷 28, 期 11, 页码 1543-1549出版社
WILEY-BLACKWELL
DOI: 10.1002/nbm.3419
关键词
MRS; brain; quantification; fat
资金
- Swiss National Science Foundation [320030_156952]
- Swiss National Science Foundation (SNF) [320030_156952] Funding Source: Swiss National Science Foundation (SNF)
It has recently been reported in this journal that local fat depots produce a sizable frequency-dependent signal attenuation in magnetic resonance spectroscopy (MRS) of the brain. If of a general nature, this effect would question the use of internal reference signals for quantification of MRS and the quantitative use of MRS as a whole. Here, it was attempted to verify this effect and pinpoint the potential causes by acquiring data with various acquisition settings, including two field strengths, two MR scanners from different vendors, different water suppression sequences, RF coils, localization sequences, echo times, and lipid/metabolite phantoms. With all settings tested, the reported effect could not be reproduced, and it is concluded that water referencing and quantitative MRS per se remain valid tools under common acquisition conditions. Copyright (c) 2015 John Wiley & Sons, Ltd.
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