期刊
JOURNAL OF COMPARATIVE PATHOLOGY
卷 151, 期 1, 页码 42-50出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcpa.2014.04.001
关键词
branched-chain DNA assay; canine mammary carcinoma; steroid receptors
资金
- Basic Science Research Programme of the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2011-0021337]
- National Research Foundation of Korea [2011-0021337] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The existence of the oestrogen receptor-negative (OR)/progesterone receptor-positive (PR+) phenotype in canine mammary carcinomas (CMCs) is not well understood, although this phenotype was reported consistently in previous studies. In the present study, immunohistochemistry (IHC) was performed to categorize CMCs with the OR-/PR+ phenotype and compare their clinicopathological features with OR+/PR+ tumours. Of a total of 305 CMCs, 36 (11.8%) were categorized as OR-/PR+ and showed intermediate characteristics between those of OR+/PR+ and OR-/PR- cases. OR mRNA levels were measured in formalin-fixed, paraffin wax-embedded samples using a novel branched-chain DNA assay method. Similar to the IHC result, one-way analysis of variance showed that the mean normalized OR mRNA level of OR-/PR+ tumours (11.4 +/- 16.34) was between that of the OR-/PR- (mean 4.7 +/-+/- 6.35) and OR+/PR+ (mean 15.8 +/- 11.95) (P = 0.033) tumours. Only three of the 36 OR-/PR+ tumours completely lacked OR mRNA expression. The OR-/PR+ tumours were not categorized as an independent group nor were they included in the other groups on post-hoc analysis. OR-/PR+ tumours were associated with factors related to poor prognosis compared with OR+/PR+ tumours, but OR-/PR- tumours were associated with the worst prognostic indicators. Further studies are required in order to deiermine the clinical significance of the OR+/PR+ phenotype. (C) 2014 Elsevier Ltd. All rights reserved.
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