期刊
JOURNAL OF COMPARATIVE PATHOLOGY
卷 151, 期 2-3, 页码 228-233出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcpa.2014.04.007
关键词
AA amyloidosis; equine recurrent uveitis; mass spectrometry
Two horses with chronic uveitis and histological lesions consistent with equine recurrent uveitis (ERU) were examined. Microscopical findings in the ciliary body included deposits of amyloid lining the non-pigmented epithelium, intracytoplasmic, rod-shaped, eosinophilic inclusions and intraepithelial infiltration of T lymphocytes. Ultrastructural examination of the ciliary body of one horse confirmed the presence of abundant extracellular deposits of non-branching fibrils (9-11 nm in diameter) consistent with amyloid. Immunohistochemistry revealed strong positive labelling for AA amyloid and mass spectrometry showed the amyloid to consist primarily of serum amyloid A1 in both cases. The findings suggest that localized, intraocular AA amyloidosis may occur in horses with ERU. (C) 2014 Elsevier Ltd. All rights reserved.
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