期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 522, 期 12, 页码 2756-2766出版社
WILEY-BLACKWELL
DOI: 10.1002/cne.23581
关键词
neurogenesis; hippocampus; dendritic spine; mushroom spine; running; enriched environment
资金
- National Institutes of Health [NS-05050217, NS-05052842]
- James S. McDonnell Foundation
- JPB Foundation
- Ellison Foundation
New neurons are continuously added to the hippocampus of adult mammals. Their survival and integration into the circuitry are highly dependent on experience. Here we show that mushroom spine formation in newborn granule cells was modulated by experience and that dendritic segments in different areas of the molecular layer were differentially regulated. Specifically, spines of new neurons in the outer molecular layer of the dentate gyrus were more readily influenced by non-spatial features in the living environment. Those in the middle molecular layer were more likely to be influenced by the size of the living environment. Therefore, the activity of cortical inputs into newborn granule cells may be reflected in the formation of mushroom spines in different dendritic segments in the molecular layer. (C) 2014 Wiley Periodicals, Inc.
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