期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 521, 期 18, 页码 4318-4338出版社
WILEY
DOI: 10.1002/cne.23428
关键词
aging; amyloid; brain; evolution; great ape; mammals; pathology; tau
资金
- National Science Foundation [BCS-0921079, BCS-0827531]
- James S. McDonnell Foundation [22002078, 22002029]
- National Institute of Aging [AG14308]
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [0827531] Funding Source: National Science Foundation
The two major histopathologic hallmarks of Alzheimer's disease (AD) are amyloid beta protein (A) plaques and neurofibrillary tangles (NFT). A pathology is a common feature in the aged nonhuman primate brain, whereas NFT are found almost exclusively in humans. Few studies have examined AD-related pathology in great apes, which are the closest phylogenetic relatives of humans. In the present study, we examined A and tau-like lesions in the neocortex and hippocampus of aged male and female western lowland gorillas using immunohistochemistry and histochemistry. Analysis revealed an age-related increase in A-immunoreactive plaques and vasculature in the gorilla brain. A plaques were more abundant in the neocortex and hippocampus of females, whereas A-positive blood vessels were more widespread in male gorillas. Plaques were also A40-, A42-, and A oligomer-immunoreactive, but only weakly thioflavine S- or 6-CN-PiB-positive in both sexes, indicative of the less fibrillar (diffuse) nature of A plaques in gorillas. Although phosphorylated neurofilament immunostaining revealed a few dystrophic neurites and neurons, choline acetyltransferase-immunoreactive fibers were not dystrophic. Neurons stained for the tau marker Alz50 were found in the neocortex and hippocampus of gorillas at all ages. Occasional Alz50-, MC1-, and AT8-immunoreactive astrocyte and oligodendrocyte coiled bodies and neuritic clusters were seen in the neocortex and hippocampus of the oldest gorillas. This study demonstrates the spontaneous presence of both A plaques and tau-like lesions in the neocortex and hippocampus in old male and female western lowland gorillas, placing this species at relevance in the context of AD research. J. Comp. Neurol. 521:4318-4338, 2013. (c) 2013 Wiley Periodicals, Inc.
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