期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 519, 期 12, 页码 2434-2474出版社
WILEY
DOI: 10.1002/cne.22635
关键词
lateral septum; immunohistochemistry; basal ganglia; amygdala; bed nucleus of the stria terminalis; dorsal raphe
资金
- National Science Foundation [IBN 9421658]
- National Institute of Mental Health [RO1 MH047538]
- T32 MH020051
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0817878] Funding Source: National Science Foundation
The neuropeptide vasopressin (AVP) has been implicated in the regulation of numerous physiological and behavioral processes. Although mice have become an important model for studying this regulation, there is no comprehensive description of AVP distribution in the mouse brain and spinal cord. With C57BL/6 mice, we used immunohistochemistry to corroborate the location of AVP-containing cells and to define the location of AVP-containing fibers throughout the mouse central nervous system. We describe AVP-immunoreactive (-ir) fibers in midbrain, hindbrain, and spinal cord areas, which have not previously been reported in mice, including innervation of the ventral tegmental area, dorsal and median raphe, lateral and medial parabrachial, solitary, ventrolateral periaqueductal gray, and interfascicular nuclei. We also provide a detailed description of AVP-ir innervation in heterogenous regions such as the amygdala, bed nucleus of the stria terminalis, and ventral fore-brain. In general, our results suggest that, compared with other species, the mouse has a particularly robust and widespread distribution of AVP-ir fibers, which, as in other species, originates from a number of different cell groups in the telencephalon and diencephalon. Our data also highlight the robust nature of AVP innervation in specific regulatory nuclei, such as the ventral tegmental area and dorsal raphe nucleus among others, that are implicated in the regulation of many behaviors. J. Comp. Neurol. 519: 2434-2474, 2011. (C) 2011 Wiley-Liss, Inc.
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