期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 517, 期 3, 页码 257-275出版社
WILEY
DOI: 10.1002/cne.22154
关键词
efferent motor map; retinal ganglion cells; retrograde tracing; retinotopy; tectum; pretectum; orienting and evasive behavior
资金
- European Union (EU) [FP6 MEST-CT-2005-019729, 001917]
- ICT-STREP [216100-LAMPETRA]
- Swedish Research Council [VR-M-3026, VR-NT 621-2007-6049]
- FP7 Health-Seclect and Act [F2-2008-201716]
- Karolinska Institutets Research funds
An important issue to understand is how visual information can influence the motor system and affect behavior. Using the lamprey (Petromyzon marinus) as an experimental model we examined the morphological subtypes of retinal ganglion cells and their projection pattern to the tectum, which controls eye, head, and body movements, and to the pretectum, which mediates both visual escape responses and the dorsal light response. We identified six distinct morphological types of retinal ganglion cell. Four of these distribute their dendrites in the inner plexiform layer (image forming layer) and project in a retinotopic manner to all areas of the tectum. The posterior part of the retina has the highest density of ganglion cells and projects to the rostral part of the tectum, in which the visual field in front of the lamprey will be represented. From this area both orienting and evasive behaviors can be elicited. In contrast, pretectum receives input from two ganglion cells types that send their dendrites only to the outer plexiform layer or the outer limiting membrane and therefore may directly contact photoreceptors, and transmit information without additional delay to pretectum, which may be particularly important for visual escape responses. One of these two types, the bipolar ganglion cell, is only found in a small patch of retina just ventral of the optic nerve. Due to its distribution, morphology, and projections we suggest that this cell may control the dorsal light response. J. Comp. Neurol. 517:257-275, 2009. (C) 2009 Wiley-Liss, Inc.
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