期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 510, 期 3, 页码 237-250出版社
WILEY
DOI: 10.1002/cne.21746
关键词
retina; transcription factors; differentiation; Sox2; Notch1
资金
- National Eye Institute [T32 EY07102, R01 EY013128]
- Ben F. Love Endowment
- [HD30284]
It is widely accepted that the process of retinal cell fate determination is under tight transcriptional control mediated by a combinatorial code of transcription factors. However, the exact repertoire of factors necessary for the genesis of each retinal cell type remains to be fully defined. Here we show that the HMG-box transcription factor, Sox9, is expressed in multipotent mouse retinal progenitor cells throughout retinogenesis. We also find that Sox9 is downregulated in differentiating neuronal populations, yet expression in Muller glial cells persists into adulthood. Furthermore, by employing a conditional knockout approach, we show that Sox9 is essential for the differentiation and/or survival of postnatal Muller glial cells.
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