期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 12, 期 5, 页码 696-699出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc100086h
关键词
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资金
- Nanyang Technological University [RG50/08]
- Ministry of Health, Singapore (NMRC) [H1N1R/001/2009]
A direct and efficient approach to 1-aminoindolizines through three-component one-pot reaction of heteroaryl aldehydes, secondary amines, and terminal alkynes catalyzed by AgBF4 has been developed. Desired products were obtained in moderate to excellent yields. Similar aminoindolizines products were afforded from trimethylsilyl protected alkyne substrates as well. This methodology provides a rapid access to construct a diversity-oriented library of indolizines.
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