期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 11, 期 6, 页码 1100-1104出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc900111u
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资金
- American Lebanese Syrian Associated Charities (ALSAC)
- St. Jude Children's Research Hospital
To identify novel potentially broad spectrum antiviral compounds against RNA viruses, we have developed the parallel synthesis of a structurally interesting class of 2-substituted-4,5-dihydroxypyrimidine-6-carboxamides. Variously 2-substituted-4,5-dihydroxypyrimidine-6-carboxylate methyl esters were initially prepared and were then diversified via a facile amidation reaction. This strategy affords libraries of thousands of diverse drug-like compounds for screening. Biological evaluation of a set of these compounds, via a small initial screen, identified antiviral compounds against a representative RNA virus (Sendai virus, a paramyxovirus). We provide details on the synthetic protocols and the in vitro antiviral activity studies, as part of our initial investigation of the resulting targeted libraries.
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