期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 11, 期 2, 页码 267-273出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc800157k
关键词
-
资金
- National Natural Science Foundation of China [30772652]
- Zhejiang Provincial Natural Science Foundation of China [Z405037]
- Program for New Century Excellent Talents in University [NCET-050523]
2,4-Diamino-6-aryl-1,3,5-triazines were synthesized by using a solid-supported approach in which monoarylsubstituted triazines were captured directly from the crude reaction mixture by resin-bound amines. The effects of the synthesized compounds on inhibition activities against tumor cell lines (PC-3, K562, A549, and HO8910) were examined. Most of the obtained compounds demonstrated remarkable antiproliferative activities against K562, PC-3, and HO8910 cell lines. Particularly, compounds 8c exhibited prominent inhibition activity with IC50 values of 1.01, 2.23, and 1.06 mu M, respectively. The structure-activity relationships of 2,4-diamino-6-aryl-1,3,5-triazines are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据