期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 11, 期 6, 页码 1061-1065出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc9000949
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资金
- National Institute of General Medical Sciences [GM070620, GM079593]
- National Institutes of Health Kansas University Chemical Methodologies and Library Development Center of Excellence [GM069663]
- Johnson Matthey, Inc
- Kawaken Fine Chemicals Co., Ltd
The solution-phase synthesis of a 111 member isoquinoline library is described. The isoquinoline scaffold has been accessed through the palladium- and copper-catalyzed cyclization of iminoalkynes and the palladium-catalyzed iminoannulation of internal alkynes, followed by diversification of hydroxyl functionality where it is present.
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