期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 430, 期 -, 页码 207-213出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2014.05.054
关键词
Nanoarrays; Cell pattern; Dip pen nanolithography; Self-assembled monolayers; Peptide nanopatterns; Surface chemistry; Nanoengineering
资金
- Carolina Center for Cancer Nanotechnology Excellence (NCI)
- Burroughs Wellcome Foundation (Interface Career Award)
- National Science Foundation (Career Award)
- National Science and Engineering Research Council of Canada (NSERC)
- Canadian Foundation for Innovation (CFI)
Proper cell polarization and division are critical for a developing organism and a number of downstream biological processes including cancer metastasis, cell migration, and organelle organization. Both cell behaviors are complex and influenced by a number of external factors including, the extracellular matrix (ECM), physical-mechanical and hydrodynamic forces. In particular, the ECM functions as a dynamic 3-dimensional scaffold support for tissue segregation and cell adhesion. Although cells are microns in size, they sense and respond to dynamic nanoarchitecture changes of the ECM. To further understand these complex processes model substrates have been developed to recapitulate the spatial presentation of ligands as gradients and single cell patterns. However, until now, the interplay between ligand affinity, ligand density and ligand area at the nanoscale on cell behavior has received little attention due to the lack of synergistic surface chemistry, microscopy, cell biology, and nanopatterning technologies. In this report, we develop biospecific nanopatterned peptide array substrates to examine how the nano-environment controls cell behavior utilizing parallel dip-pen nanolithography. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据