期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 394, 期 -, 页码 590-597出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2012.11.041
关键词
Collagen; Plasma functionalization; Osteoblasts; Tissue engineering; Nanomedicine applications
资金
- Fondazione Cariplo [2010-0378]
- 5x1000 2009 Rizzoli Orthopaedic Institute
Type I collagen films have been functionalized on their surfaces by plasma treatment with carboxyl and amino groups to improve their potential for grafting bioactive molecules. The physico-chemical properties of the plasma-treated films were evaluated and compared to the untreated materials by water contact angle, SEM and AFM. The presence of new functional groups on the film surfaces has been assessed by ATR-FTIR spectra after chemical derivatization. Moreover, the biocompatibility of the plasma-treated films was studied with MG-63 human osteoblast-like cells, evaluating cell proliferation, viability and morphology at 1, 3 and 7 days. (C) 2012 Elsevier Inc. All rights reserved.
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