4.7 Article

Targeted therapy of SMMC-7721 liver cancer in vitro and in vivo with carbon nanotubes based drug delivery system

期刊

JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 365, 期 1, 页码 143-149

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.09.013

关键词

Carbon nanotubes; Chitosan; Folic acid; Drug delivery system; Liver cancer

资金

  1. National Science Fund for Distinguished Young Scholars [50925310]
  2. National Science Foundation of China [20874059, 20904030, 21174087]
  3. High Technology Research and Development Program of China (863 Project) [2009AA03Z329]
  4. Shanghai Science and Technology Commission [10410709400, 10411950100]
  5. Shanghai Talent Development Foundation [2009-035]

向作者/读者索取更多资源

A new type of drug delivery system (DDS) involved chitosan (CHI) modified single walled carbon nanotubes (SWNTs) for controllable loading/release of anti-cancer doxorubicin (DOX) was constructed. CHI was non-covalently wrapped around SWNTs, imparting water-solubility and biocompatibility to the nanotubes. Folic acid (FA) was also bounded to the outer CHI layer to realize selective killing of tumor cells. The targeting DDS could effectively kill the HCC SMMC-7721 cell lines and depress the growth of liver cancer in nude mice, showing superior pharmaceutical efficiency to free DOX. The results of the blood routine and serum biochemical parameters, combined with the histological examinations of vital organs, demonstrating that the targeting DDS had negligible in vivo toxicity. Thus, this DDS is promising for high treatment efficacy and low side effects for future cancer therapy. (C) 2011 Elsevier Inc. All rights reserved.

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