期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 376, 期 -, 页码 119-125出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2012.02.029
关键词
Giant lipid vesicles; Microfluidics; Water-in-oil emulsion; Micro-reaction compartment
资金
- Special Coordination Funds for Promoting Science and Technology: Yuragi Project
- Global COE (Centers of Excellence) of the Japanese Ministry of Education, Culture, Sports, Science and Technology
The production of giant lipid vesicles with controlled size and structure will be an important technology in the design of quantitative biological assays in cell-mimetic microcompartments. For establishing size control of giant vesicles, we investigated the vesicle formation process, in which inverted emulsion droplets are transformed into giant unilamellar vesicles (GUVs) when they pass through an oil/water interface. The relationship between the size of the template emulsion and the converted GUVs was studied using inverted emulsion droplets with a narrow size distribution, which were prepared by microfluidics. We successfully found an appropriate centrifugal acceleration condition to obtain GUVs that had a desired size and narrow-enough size distribution with an improved yield so that emulsion droplets can become the template for GUVs. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
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