期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 361, 期 1, 页码 16-24出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.05.038
关键词
Magnetic; Mesoporous silica nanoparticles; Seeded growth; Pore swelling; DNA adsorption
资金
- National 863 High-Tech Program [2009AA03Z333]
- NSFC [21050110117]
- TEKES (the Finnish Funding Agency for Technology and Innovation) NAMI (China - Finland Nanotechnology Strategic Mutual Collaboration Initiative) [19807]
- International Cooperation Project of PR China [2008DFA51860]
- Shanghai Nano Project [1052nm01100]
- SJTU [YG2009ZD203, YG2010ZD102]
Magnetic mesoporous silica nanoparticles (M-MSNs) are emerging as one of the most appealing candidates for theranostic carriers. Herein, a simple synthesis method of M-MSNs with a single Fe(3)O(4) nanocrystal core and a mesoporous shell with radially aligned pores was elaborated using tetraethyl orthosilicate (TEOS) as silica source, cationic surfactant CTAB as template, and 1,3,5-triisopropylbenzene (TMB)/decane as pore swelling agents. Due to the special localization of TMB during the synthesis process, the pore size was increased with added TMB amount within a limited range, while further employment of TMB lead to severe particle coalescence and not well-developed pore structure. On the other hand, when a proper amount of decane was jointly incorporated with limited amounts of TMB, effective pore expansion of M-MSNs similar to that of analogous mesoporous silica nanoparticles was realized. The resultant M-MSN materials possessed smaller particle size (about 40-70 nm in diameter), tunable pore sizes (3.8-6.1 nm), high surface areas (700-1100 m(2)/g), and large pore volumes (0.44-1.54 cm(3)/g). We also demonstrate their high potential in conventional DNA loading. Maximum loading capacity of salmon sperm DNA (375 mg/g) was obtained by the use of the M-MSN sample with the largest pore size of 6.1 nm. (C) 2011 Elsevier Inc. All rights reserved.
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