期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 364, 期 1, 页码 92-99出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.08.028
关键词
Mixed micelles; pH-Sensitivity; Star copolymer; Self-assembly; Drug release
资金
- Fundamental Research Funds for the Central Universities [WD0913008, WD1014017]
- Shanghai Municipal Education Commission
- Shanghai Leading Academic Discipline Project [B502]
- Shanghai Key Laboratory [08DZ2230500]
- Natural Science Foundation of Shanghai [11ZR1409200]
- Changjiang Scholars and Innovative Research Team in University [IRT0825]
Comicellization of a star block copolymer poly(epsilon-caprolactone)-block-poly(diethylamino)ethyl methacrylate (S(PCL-b-PDEAEMA)) and a linear block copolymer methoxy poly(ethylene glycol)-block-poly(epsilon-caprolactone) (mPEG-b-PCL) was developed to enhance the stability and lower the cytotoxicity of the micelles. The two copolymers self-assembled into the mixed micelles with a common PCL core surrounded by a mixed PDEAEMA/mPEG shell in aqueous solution. This core-shell structure was transformed to the core-shell-corona structure at high pH due to the collapse of the PDEAEMA segment. The properties of the polymeric micelles were greatly dependent on the weight ratio of the two copolymers and the external pH. As increasing the mPEG-b-PCL content, the size and the zeta potential of the mixed micelles were lowered while the pH-dependent stability and the biocompatibility were improved. Moreover, an increase in pH accelerated the release of indomethacin (IND) from the mixed micelles in vitro. These results augured that the mixed micelles could be applied as a stable pH-sensitive release system. (C) 2011 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据