期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 344, 期 1, 页码 158-164出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2009.12.022
关键词
Imprinted sol-gel sensor; Layer-by-layer assembly; Multi-wall carbon nanotube; Clindamycin
资金
- Natural Science Foundation of Hunan Province, China [08JJ4004]
- Research Foundation of Education Bureau of Hunan Province, China [07B061]
A novel sensitive molecularly imprinted electrochemical sensor was constructed for selective detection of clindamycin by combination of a multi-wall carbon nanotube (MWNT) layer with a thin molecularly imprinted sol-gel film. The sensor was fabricated onto Au electrode via stepwise modification of MWNT and a thin sol-gel film of molecularly imprinted polymers (MIP) by using electrodeposition method. The molecularly imprinted film displayed excellent selectivity towards clindamycin. Due to such combination, the sensor responded quickly to clindamycin. The response peak current was linear to the concentration of clindamycin in the range from 5.0 x 10(-7) mol L-1 to 8.0 x 10(-5) mol L-1, and the detection limit was 2.44 x 10(-8) mol L-1. This imprinted sensor was applied to the determination of clindamycin in human urine samples successfully. These results revealed that the imprinted sensor fulfilled the selectivity, sensitivity, speed and simplicity requirements for clindamycin detection, and provided possibilities of clinical application in physiological fluids. (C) 2009 Elsevier Inc. All rights reserved.
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