期刊
JOURNAL OF COGNITIVE NEUROSCIENCE
卷 23, 期 5, 页码 1218-1229出版社
MIT PRESS
DOI: 10.1162/jocn.2010.21514
关键词
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资金
- Parkinson Disease Society [RG47229]
- Medical Research Council [G0001354B, G0300723B, G0001354] Funding Source: researchfish
This study presents the first direct investigation of the hypothesis that dopamine depletion of the dorsal striatum in mild Parkinson disease leads to impaired stimulus-response habit formation, thereby rendering behavior slow and effortful. However, using an instrumental conflict task, we show that patients are able to rely on direct stimulus-response associations when a goal-directed strategy causes response conflict, suggesting that habit formation is not impaired. If anything our results suggest a disease severity-dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior.
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