期刊
JOURNAL OF CLINICAL VIROLOGY
卷 59, 期 4, 页码 218-222出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jcv.2014.01.023
关键词
Hepatitis C virus; HIV; Memory B-lymphocytes; Pathogenesisa
类别
资金
- Young Researcher's Group grant of the European Social Funds
- Ministry of Science and Culture of the State of Saxony, Germany
- Young Researcher grant of the Faculty of Medicine of the University of Leipzig
Antibody responses to hepatitis C virus (HCV) occur delayed and overly decline after viral clearance indicating that the B-cell response to HCV is abnormal. Virus-specific memory B-cells have recently been found in infected individuals, but the viral exposure requirements for the generation of these cells is unknown. Objectives: The primary goal of this study was to quantify and compare the HCV-specific memory B-cell response between chronic and resolved HCV-infected individuals. A secondary goal was to examine if HIV-specific memory B-cell responses are maintained during HCV co-infection. Study design: HCV core protein- and HIV-specific memory B-cell responses were examined in HIV/HCV-infected individuals treated 4-30 weeks after HCV diagnosis. Memory B-cell frequencies were compared between chronically and transiently infected individuals. Results: Chronically infected individuals had vigorous HCV-specific memory B-cell responses and antibodies, whereas subjects with transient viremia showed low or undetectable virus-specific B-cell responses. In addition, chronically HIV/HCV-infected subjects had robust HIV-specific memory B-cell responses. Conclusions: Whereas chronic HCV infection induces virus-specific antibodies and memory B-cells, transient infection in individuals with sustained viral response to therapy does not stimulate a durable HCV-specific B-cell response indicating that the formation of long-lived virus-specific B-cells is suppressed in the early phase of infection. This may contribute to the inability to spontaneously clear HCV infection. (C) 2014 Elsevier B.V. All rights reserved.
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