期刊
JOURNAL OF CLINICAL VIROLOGY
卷 58, 期 1, 页码 67-73出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jcv.2013.06.035
关键词
Liver transplantation; Hepatitis B; Prevention; Tenofovir; Emtricitabine; Immunoglobulin
类别
资金
- Gilead Sciences
Background: After orthotopic liver transplantation (OLT) in chronic hepatitis B (HBV), adequate prophylaxis for recurrence of HBV in the graft is mandatory. Objectives: Evaluate safety of HBV prophylaxis with tenofovir and emtricitabine (TDF/FTC) after cessation of hepatitis B immunoglobulin (HBIG) after OLT in chronic HBV. Study design: In 17 consecutive patients after OLT in chronic HBV we started TDF/FTC after cessation of HBIG. All had received HBIG > 6 months. 15/17 were HBsAg negative and 16/17 had undetectable HBV-DNA. Results: After mean follow-up of 2 years 16/17 patients were alive, one died due to urosepsis. All 16 with undetectable HBV-DNA remained HBV-DNA negative. From 15 HBsAg negative patients at start, in one seroconversion to positive HBsAg occurred, without detectable HBV-DNA. Liver biochemistry remained within the normal ranges. There were no cases of drug discontinuation. No major side effects were reported. TDF/FTC use saves (sic) 16,262/year over standard-of-care (HBIG + LAM). This prospective follow-up study shows that in liver transplantation for chronic hepatitis B, after initial treatment including HBIG for at least 6 months combined with or followed by (dual) nucleos(t)ide analog therapy, TDF/FTC provides adequate prophylaxis against recurrent HBV infection without major side effects and leads to substantial cost savings over a regimen with HBIG. Conclusion: Combined prophylaxis with TDF/ETV nucleoside plus nucleotide analogs and cessation of immunoglobulin after liver transplantation in chronic hepatitis B is safe and effective. (C) 2013 Elsevier B. V. All rights reserved.
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