期刊
JOURNAL OF CLINICAL VIROLOGY
卷 50, 期 3, 页码 194-200出版社
ELSEVIER
DOI: 10.1016/j.jcv.2010.12.006
关键词
Vitamin D; LL-37; Anti-viral; Human beta defensin 2; RTIs
类别
资金
- NIH [T32 GM07215]
- Clinical Science Development Service of the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development [I01CX000117]
Vitamin D has long been recognized as essential to the skeletal system. Newer evidence suggests that it also plays a major role regulating the immune system, perhaps including immune responses to viral infection. Interventional and observational epidemiological studies provide evidence that vitamin D deficiency may confer increased risk of influenza and respiratory tract infection. Vitamin D deficiency is also prevalent among patients with HIV infection. Cell culture experiments support the thesis that vitamin D has direct anti-viral effects particularly against enveloped viruses. Though vitamin D's anti-viral mechanism has not been fully established, it may be linked to vitamin D's ability to up-regulate the anti-microbial peptides LL-37 and human beta defensin 2. Additional studies are necessary to fully elucidate the efficacy and mechanism of vitamin D as an anti-viral agent. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据