期刊
JOURNAL OF CLINICAL VIROLOGY
卷 47, 期 4, 页码 382-386出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jcv.2010.01.011
关键词
Mixed HCV infection; Subdominant genotype; HCV recombinant strain
类别
资金
- Agence Nationale de la Recherche sur le SIDA
To date, few natural intergenotypic recombinant hepatitis C virus (HCV) strains have been characterized. A recombinant strain 2k/1b was detected for one HCV RNA- positive individual who had just completed therapy for HCV 3a genotype infection. In the present report, five serum samples collected over the preand post- treatment periods were used to investigate all the present HCV strains and the change over time of the infection pattern. Interestingly, the 2k/1b strain was already present during the genotype 3a infection and persisted during treatment. In the specimen collected three months post-treatment, two distinct strains, 2k/1b and type 1, were found and then one 2k/1b strain in the subsequent ones. A genomic variant of the HCV RF1 2k/1b strain was identified. It was part of a mixed HCV infection and persisted and re-emerge after eradication of the dominant subtype 3a. This case indicates that HCV co-infection screening after relapse should be an alternative to explain the lack of response to treatment and the necessity to carefully study the epidemic spreading of this recombinant strain. (C) 2010 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据