期刊
JOURNAL OF CLINICAL VIROLOGY
卷 41, 期 2, 页码 160-163出版社
ELSEVIER
DOI: 10.1016/j.jcv.2007.11.005
关键词
HCV/HIV-1 coinfection; HAART; HCV clearance; T cell activation; T cell function
类别
Background/objective: Spontaneous HCV clearance in HCV/HIV-1 coinfected patients is likely to be very rare given the damage to the immune system caused by HIV-1 infection. The search for immune correlates of spontaneous clearance is important for the understanding of pathogenesis as well as for the development of possible new treatment strategies. Study design/results: A cohort of HCV/HIV-1 coinfected patients was followed. Plasma HCV viral load was measured and T cell immunity in peripheral blood samples was assessed using multi-color flow cytometry. One HCV/HIV-1 coinfected patient spontaneously became HCV-RNA negative after being positive for several years. This patient displayed a normalized CD4 counts on successful HAART, low level of T cell activation and a high level of T cell function as compared to HCV/HIV-1 coinfected control subjects. Conclusions: A beneficial immune status including a low level of chronic T cell activation and a high level of T cell function may be one factor that contributes to improved chances of clearance of chronic HCV infection in HIV-1 infected patients. (c) 2007 Elsevier B.V. All rights reserved.
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